ISOLUTE® HM-N is a modified form of diatomaceous earth. The support has many uses in reaction work-up, including:
The use of a support eliminates emulsion formation at the interface of the two liquids. All protocols using ISOLUTE HM-N are processed using gravity flow.
When removing polar compounds or salts from reaction mixtures, an aqueous solution is initially immobilized on the ISOLUTE HM-N support. As the reaction mixture is applied to the cartridge, water soluble impurities transfer to the aqueous phase with the target compound remaining in the water-immiscible organic solvent.
ISOLUTE HM-N removes trace amounts of water from water-immiscible organic solvents. The maximum amount of water that can be adsorbed is 750 µL per g of ISOLUTE HM-N. This capacity may vary depending on the solvent used.