The typical peptide synthesis workflow broadly involves synthesis, purification and evaporation steps to give the final pure peptide. Although the synthesis step is the most important part of the workflow, purification and evaporation issues can impact dramatically on the efficiency of your workflow and are the cause of many bottlenecks. Biotage has developed a range of tools to improve the peptide synthesis workflow, from synthesis of crude peptides through to the final purified product. These solutions make your workflow more efficient and improve the quality of peptides you synthesize. Our workflow solutions are used in pharma, biotech, CRO and academic laboratories throughout the world.

The study of peptides, especially for therapeutic use, has grown significantly in recent years. However, producing peptides for such research is challenging, not just in the synthesis. The molecules must be visualized to allow synthetic approaches to be designed, and after synthesis the purification and isolation of peptides is not straightforward. In order to address these challenges, Biotage has developed a holistic approach to the entire peptide workflow via an automated solution, designed for dedicated peptide researchers and those new to the field.

Peptides have garnered much attention in a variety of applications over the last few years, and interest only continues to grow. With improved synthetic strategies, peptides are now being synthesized in greater length and complexity than ever before. Purification of peptides via flash chromatography has recently been demonstrated as a viable alternative to the more standard HPLC methods currently utilized,  offering the advantage of significantly greater loading capacity while  reducing the overall purification time. Herein we present several strategies that allow for very high purity peptide samples purified by flash chromatography.