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ISOLUTE® SCX-2 is a silica-based media with a chemically bonded propylsulfonic acid functional group. It is used for the isolation of a wide range of basic compounds using both catch & release and scavenging protocols. ISOLUTE SCX-2 is available packed into SPE cartridges for flow-through. Using the catch & release approach, basic target compounds can be isolated from a range of reaction mixtures. ISOLUTE SCX-2 cartridges can be used to remove excess basic reagents, allowing neutral or acidic compounds to pass straight through to the collection vessel.
During catch & release the media bed "catches” the compound of interest. Rinsing the cartridge with solvent removes impurities, leaving the compound of interest on the cartridge for subsequent elution by an appropriate solvent. Biotage has a range of cartridges depending on whether the product to be recovered is acidic, basic or neutral. Applications include: purification, solvent switch, concentrating & capturing and HPLC fractions.
Overall Process:
It may also be possible to retain impurities in step 3, such that the cartridge becomes a one pass, one step purification system.
Further Notes: equilibration, loading and elution solvents may be substituted. Base cartridge loading calculations on approx. 60% cartridge capacity for initial run, depending
on the product, loading may be increased further following optimization.

| Part No. | Description | Pack Size | List Price | |
|---|---|---|---|---|
| 456-1000-F | ISOLUTE® FLASH SCX-2 10 g/70 mL | 16 | 442 USD | Add to quote/cart |
| 456-0100-C | ISOLUTE® FLASH SCX-2 1g/6ml | 30 | 175 USD | Add to quote/cart |
| 456-0200-D | ISOLUTE® FLASH SCX-2 2 g/15 mL | 20 | 175 USD | Add to quote/cart |
| 456-0200-DG | ISOLUTE® FLASH SCX-2 2 g/15 mL | 20 | 209 USD | Add to quote/cart |
| 456-2000-F | ISOLUTE® FLASH SCX-2 20 g/70 mL | 16 | 874 USD | Add to quote/cart |
| 456-2500-J | ISOLUTE® FLASH SCX-2 25 g/150 mL | 8 | 535 USD | Add to quote/cart |
| 456-0500-E | ISOLUTE® FLASH SCX-2 5 g/25 mL | 20 | 312 USD | Add to quote/cart |
| 456-5000-J | ISOLUTE® FLASH SCX-2 50 g/150 mL | 8 | 1054 USD | Add to quote/cart |
| 456-0050-B | ISOLUTE® FLASH SCX-2 500 mg/3 mL | 50 | 193 USD | Add to quote/cart |
| 456-7000-J | ISOLUTE® FLASH SCX-2 70 g/150 mL | 8 | 1469 USD | Add to quote/cart |
| 988-1000-F | ISOLUTE® PE-AX/SCX-2 10 /70 mL | 16 | 887 USD | Add to quote/cart |
| 988-2000-F | ISOLUTE® PE-AX/SCX-2 20 g/70 mL | 16 | 1715 USD | Add to quote/cart |
| 988-0500-E | ISOLUTE® PE-AX/SCX-2 5 g/25 mL | 20 | 575 USD | Add to quote/cart |
| 532-1000-F | ISOLUTE® SCX-2 10 g/70 mL | 16 | 486 USD | Add to quote/cart |
| 532-0500-E | ISOLUTE® SCX-2 5 g/25 mL | 20 | 402 USD | Add to quote/cart |
| 440-0050-CG | ISOLUTE® SCX-2 500 mg/6 mL (Tabless) | 30 | 97 USD | Add to quote/cart |
Biotage is a Global Impact Tech Company committed to solving society’s problems. We offer workflow solutions and products to customers in drug discovery and development and diagnostics, analytical testing and water and environmental testing.
Biotage is contributing to sustainable science with the goal to make the world healthier, greener and cleaner – HumanKind Unlimited.
Our customers span a broad range of market segments including pharmaceutical, biotech, diagnostic, contract research and contract manufacturers as well as clinical, forensic and academic laboratories in addition to organizations focused on food safety, clean water and environmental sustainability.
Biotage is headquartered in Uppsala in Sweden and employs appr. 700 people worldwide. The Group had sales of 1,566 MSEK in 2022 and our products are sold in more than 80 countries. Biotage’s share (BIOT) is listed in the Large Cap segment on the NASDAQ Stockholm.
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