Applicability of a Novel Automation Platform for Column-based Drug of Abuse Extraction prior to LC/MS or GC/MS Analysis

Historically, silica-based solid phase extraction (SPE) columns have been used for drugs of abuse testing, the exact choice being dependent on drug functionality. GC/MS sensitivity requirements traditionally dictated larger volume sampling resulting in the use of columns capable of accepting volumes up to 10 mL. Reduced sample size has been achieved due to increased specificity using GC-MS/MS or the movement to LC-MS/MS analysis. This poster will present a dedicated sample preparation platform capable of processing volumes associated with drugs of abuse testing whether using GC/MS or LC/MS end points.