Documents|Extraction of Amphetamine and Designer Amphetamine Analogues from Whole Blood Using ISOLUTE® SLE+ Prior to GC/MS Analysis
Extraction of Amphetamine and Designer Amphetamine Analogues from Whole Blood Using ISOLUTE® SLE+ Prior to GC/MS Analysis
This application note describes the extraction of a range of amphetamine-type compounds from whole blood, prior to GC/MS analysis. A protocol that allows the simultaneous extraction of various other drugs of abuse classes: barbiturates, benzodiazepines, cocaine and opiates, is also evaluated.
ISOLUTE® SLE+ columns with 1 mL sample capacity are used to extract whole blood samples following a straightforward sample dilution. No protein precipitation or other pre-treatment is required prior to sample loading. The sample preparation procedure delivers clean extracts, good recoveries and RSD values and LLOQs from 10 ng/mL (analyte dependant).
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