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    Documents | Reducing Evaporative Crosstalk in Urine Assays Using 96-well Plates for LC-MS/MS Analysis

    Reducing Evaporative Crosstalk in Urine Assays Using 96-well Plates for LC-MS/MS Analysis

    LC-MS/MS analysis of volatile analytes is problematic when 96-well plates are used. Solid phase extraction of urine with high drug concentrations can cause contamination of the elution solvent during evaporation as the compounds volatilize then redistribute in adjacent wells.This phenomenon, known as evaporative crosstalk"

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