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    Mixed-Mode SPE

    All the SPE phases on this page extract ionizable analytes from biological fluids using a robust dual retention mechanism, which allows additional wash steps for enhanced extract purity.
    • Extract basic analytes using mixed-mode non-polar/cation exchange sorbents
    • Extract acidic analytes using mixed-mode non-polar/anion exchange sorbents
    cond-equil-load-wash-elute

    Extract basic analytes using combined non-polar and strong cation exchange retention mechanisms.

    ISOLUTE® HCX

    Extract basic analytes using combined non-polar and strong cation exchange retention mechanisms. Strong non-polar character for enhanced recovery of more polar compounds.

    ISOLUTE® HCX-3

    Extract basic analytes using combined non-polar and strong cation exchange retention mechanisms. Reduced non-polar character for higher purity extracts of more hydrophobic compounds.

    ISOLUTE® HCX-5

    Extract strongly basic (e.g. quaternary amine)  analytes using combined non-polar and weak cation exchange retention mechanisms.

    ISOLUTE® HCX-Q

    Extract acidic analytes using combined non-polar and strong anion exchange retention mechanisms.

    ISOLUTE® HAX

    About Biotage

    Biotage is a global supplier and solutions partner to a wide range of customers within drug discovery and development and analytical testing. With strong expertise in separation and purification technologies, and a focus on leveraging intelligent workflow solutions, we aim to efficiently support the advancement and protection of human health.

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    ISOLUTE Mixed-Mode Solid Phase Extraction (SPE)