Oral Fluid

    Highlighted Applications

    Oral fluid is of increasing importance as a biological matrix in drugs of abuse and related analyte testing because of the ease of sample collection, and difficulty in adulteration of samples, particularly when compared with urine.

    Practical Considerations Using Quantisal® Oral Fluid Collection Devices

    Collection devices contain components such as buffer salts and surfactants which along with typical endogenous oral fluid constituents present particular challenges in sample preparation for LC-MS/MS.

    This white paper explores strategies to maximize analyte recovery and minimize matrix effects for 85 common drugs of abuse.


    Simple Extraction of Oral Fluid Drugs Panel

    This application note describes a simple supported liquid extraction 'Load-Wait-Elute' protocol for extraction of 47 drugs of abuse (including amphetamines, opiates, benzodiazepines, and z-drugs) from oral fluid collected using the Quantisal™ collection device.

    High recoveries and low matrix effects allow for limits of detection in the mid pg/mL range using LC-MS/MS.




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    Practical Considerations Oral Fluid Collection Devices & SPE Method Development by Polymeric Mixed-Mode Cation Exchange.

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