Highlighted Applications
Oral fluid is of increasing importance as a biological matrix in drugs of abuse and related analyte testing because of the ease of sample collection, and difficulty in adulteration of samples, particularly when compared with urine.
Collection devices contain components such as buffer salts and surfactants which along with typical endogenous oral fluid constituents present particular challenges in sample preparation for LC-MS/MS.
This white paper explores strategies to maximize analyte recovery and minimize matrix effects for 85 common drugs of abuse.
This application note describes a simple supported liquid extraction 'Load-Wait-Elute' protocol for extraction of 47 drugs of abuse (including amphetamines, opiates, benzodiazepines, and z-drugs) from oral fluid collected using the Quantisal™ collection device.
High recoveries and low matrix effects allow for limits of detection in the mid pg/mL range using LC-MS/MS.
Biotage offer a wide range of optimized application notes and our new Application Notes Finder is under construction. In the meantime, don't hesitate to contact us. Our team of application specialists is here to support you!
Supported Liquid Extraction plates and columns designed to provide high analyte recoveries, and clean, protein and phospholipid free extracts. Methods are easy to develop, and automation is simple.
Eliminate conditioning and equilibration with EVOLUTE® EXPRESS load-wash-elute SPE. Robust, reliable SPE, giving ultra-pure extracts and high recoveries. Specifically developed for quantification by LC-MS/MS.
SPE columns, 96-well plates and disks: Polymeric, Non-polar, Polar, Ion exchange, Mixed-mode, Speciality media.
Consistent, uniform flow of positive pressure to move both low and high viscosity liquids through plates and columns.
Powerful, user friendly automation system for Supported Liquid Extraction (SLE), Solid Phase Extraction (SPE), Phospholipid Depletion (PLD) and Protein Precipitation (PPT) based methods, in plate or column formats.
Solvent evaporation of up to 48 samples with independent control of flow in each row. Designed to streamline your workflow following sample processing on a PRESSURE+ 48 unit.
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