ISOLUTE® HCX is a mixed-mode sorbent providing clean extracts for basic compounds from complex biological fluid samples using a dual retention mechanism.
ISOLUTE® HCX combines non-polar (C8) and strong cation exchange retention (SO3-) mechanisms to isolate basic analytes from complex aqueous matrices such as urine and plasma.
Analytes are initially retained by a non-polar retention mechanism, with inorganic salts, polar interferences such as phospholipids and large molecular weight peptides and proteins passing directly through the sorbent bed. The pH is then adjusted to allow an ion exchange retention mechanism to retain the analyte(s). Non-polar interferences are removed using an organic solvent or organic solvent/water wash. Analytes are then eluted in an extra clean fraction.
ISOLUTE HCX is the most commonly used sorbent for extraction of drugs of abuse from biological fluid samples. A number of application notes describing the extraction of common drugs of abuse classes are available.
ISOLUTE HCX is available in a wide range of SPE columns and 96-well plate formats.
Part No. | Description | Pack Size | List Price | |
---|---|---|---|---|
902-0010-A | ISOLUTE® HCX 100 mg/1 mL | 100 | 348 USD | Add to quote/cart |
902-0100-T | ISOLUTE® HCX 100 mg/2 mL Array Wells | 100 | 379 USD | Add to quote/cart |
902-0010-B | ISOLUTE® HCX 100 mg/3 mL | 50 | 186 USD | Add to quote/cart |
902-0013-A | ISOLUTE® HCX 130 mg/1 mL | 100 | 348 USD | Add to quote/cart |
902-0013-H | ISOLUTE® HCX 130 mg/10 mL (3 mL XL) | 50 | 186 USD | Add to quote/cart |
902-0013-H-500 | ISOLUTE® HCX 130 mg/10 mL (3 mL XL) | 500 | 1619 USD | Add to quote/cart |
902-0013-B | ISOLUTE® HCX 130 mg/3 mL | 50 | 186 USD | Add to quote/cart |
902-0013-B-500 | ISOLUTE® HCX 130 mg/3 mL | 500 | 1790 USD | Add to quote/cart |
902-0013-BA | ISOLUTE® HCX 130 mg/3 mL (ASPEC Adaptor) | 50 | 239 USD | Add to quote/cart |
902-0013-C | ISOLUTE® HCX 130 mg/6 mL | 30 | 142 USD | Add to quote/cart |
902-0013-C-100 | ISOLUTE® HCX 130 mg/6 mL | 100 | 403 USD | Add to quote/cart |
902-0020-H | ISOLUTE® HCX 200 mg/10 mL (3 mL XL) | 50 | 186 USD | Add to quote/cart |
902-0020-B | ISOLUTE® HCX 200 mg/3 mL | 50 | 186 USD | Add to quote/cart |
902-0002-A | ISOLUTE® HCX 25 mg/1 mL | 100 | 297 USD | Add to quote/cart |
902-0030-H | ISOLUTE® HCX 300 mg/10 mL (3 mL XL) | 50 | 186 USD | Add to quote/cart |
902-0030-B | ISOLUTE® HCX 300 mg/3 mL | 50 | 186 USD | Add to quote/cart |
902-0030-BG | ISOLUTE® HCX 300 mg/3 mL (Tabless) | 50 | 180 USD | Add to quote/cart |
902-0030-C | ISOLUTE® HCX 300 mg/6 mL | 30 | 148 USD | Add to quote/cart |
902-0005-A | ISOLUTE® HCX 50 mg/1 mL | 100 | 312 USD | Add to quote/cart |
902-0050-C | ISOLUTE® HCX 500 mg/6 mL | 30 | 142 USD | Add to quote/cart |
902-0100-P01 | ISOLUTE®-96 HCX 100 mg Fixed Well Plate | 1 | 438 USD | Add to quote/cart |
902-0025-P01 | ISOLUTE®-96 HCX 25 mg Fixed Well Plate | 1 | 407 USD | Add to quote/cart |
Biotage is a global supplier and solutions partner to a wide range of customers within drug discovery and development and analytical testing. With strong expertise in separation and purification technologies, and a focus on leveraging intelligent workflow solutions, we aim to efficiently support the advancement and protection of human health.
Copyright © 2025 Biotage