Clinical & Bioanalytical Sample Preparation

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Therapeutic Drug Research

Highlighted Applications

Fast turnaround is key, and simple, robust methodology is essential for analysis of therapeutic drugs.

Whether it's for analysis by LC-MS/MS or LC-UV, sample preparation will clean up biological fluid samples and help you detect drugs in the correct therapeutic range.

A variety of sample preparation techniques and applications are highlighted here, but if you would like to discuss your sample preparation needs, contact one of our technical experts.

biomark002.297 - LC MS Multiple Analysis

Extraction of Therapeutic Drugs from Plasma

These simple clean-up methodologies are ideal for therapeutic drug monitoring applications for a variety of commonly used drugs:

Mycophenolic Acid

Voriconazole

Axitinib

GS-441524 (Remdesivir metabolite)

Immunosuppressants in Whole Blood

Immunosuppressants inhibit or prevent the activity of the immune system used to prevent rejection of transplanted organs and treat autoimmune diseases. Due to the risks of immunodeficiency, those under treatment must undergo constant therapeutic drug monitoring (TDM) requiring reliable and robust analytical techniques for quantification of these drugs.

Sirolimus, Tacrolimus, Everolimus and Cyclosporin A

Therapeutic Peptides

Solid Phase extraction (SPE) will clean up samples and allow for robust analysis. These application notes describe SPE methods for a number of therapeutic peptides:

Desmopressin in Serum

Teicoplanin in Plasma

Oxytocin and Vasopressin in Serum

Application Note Finder

Biotage offer a wide range of optimized application notes and our new Application Notes Finder is under construction. In the meantime, don't hesitate to contact us. Our team of application specialists is here to support you!

Recommended Products

ISOLUTE® SLE+

Supported Liquid Extraction plates and columns designed to provide high analyte recoveries, and clean, protein and phospholipid free extracts. Methods are easy to develop, and automation is simple.

ISOLUTE® PLD+

Protein & Phospholipid Removal products are effective sample clean-up for LC-MS/MS analysis. Easily integrated into routine workflow, increasing productivity and reducing instrument downtime.

BIOMARK002.173 - Vitamin test Evo Express ABN

EVOLUTE® EXPRESS ABN

Eliminate conditioning and equilibration with EVOLUTE® EXPRESS load-wash-elute SPE. Robust, reliable SPE, giving ultra-pure extracts and high recoveries. Specifically developed for quantification by LC-MS/MS.

Positive Pressure Processing

Consistent, uniform flow of positive pressure to move both low and high viscosity liquids through plates and columns.

Extrahera™

Powerful, user friendly automation system for Supported Liquid Extraction (SLE), Solid Phase Extraction (SPE), Phospholipid Depletion (PLD) and Protein Precipitation (PPT) based methods, in plate or column formats.

96 Well Plate Evaporators

Designed for high throughput laboratories, to provide efficient solvent evaporation in microplate formats.

High Quality Sample Prep is Critical in Analytical Labs

Analytical laboratories using techniques such as LC-MS/MS or GC-MS are continuously searching for ways to increase throughput, reduce turnaround times and lower costs.

Resources

Clinical Applications Compendium

Selection of clinical sample preparation applications from Biotage.

Get Started with Supported Liquid Extraction

Method development chart, tips and tricks and useful insights to optimize your sample prep.

Avoiding Cross Talk 96-well Based Sample Preparation

Eliminate carryover between samples, and reduce the risk of false positive results.

Watch the Webinar

A New, Streamlined Approach to Multiple Immunosuppressant Sample Preparation for LCMS analysis.

Need support? Contact us

Make your life easier. Simplify your workflow

Automated sample preparation reduces errors, improves method robustness and frees up laboratory personnel for other tasks.