Nurse and doctor next to a patient in hospital ward-1

    Therapeutic Drug Research

    Highlighted Applications

    Fast turnaround is key, and simple, robust methodology is essential for analysis of therapeutic drugs.

    Whether it's for analysis by LC-MS/MS or LC-UV, sample preparation will clean up biological fluid samples and help you detect drugs in the correct therapeutic range.

    A variety of sample preparation techniques and applications are highlighted here, but if you would like to discuss your sample preparation needs, contact one of our technical experts.

    biomark002.297 - LC MS Multiple Analysis

    Extraction of Therapeutic Drugs from Plasma

    These simple clean-up methodologies are ideal for therapeutic drug monitoring applications for a variety of commonly used drugs:

    Mycophenolic Acid



    GS-441524 (Remdesivir metabolite)

    Immunosuppressants in Whole Blood

    Immunosuppressants inhibit or prevent the activity of the immune system used to prevent rejection of transplanted organs and treat autoimmune diseases. Due to the risks of immunodeficiency, those under treatment must undergo constant therapeutic drug monitoring (TDM) requiring reliable and robust analytical techniques for quantification of these drugs.

    Sirolimus, Tacrolimus, Everolimus and Cyclosporin A

    Therapeutic Peptides

    Solid Phase extraction (SPE) will clean up samples and allow for robust analysis. These application notes describe SPE methods for a number of therapeutic peptides:

    Desmopressin in Serum

    Teicoplanin in Plasma

    Oxytocin and Vasopressin in Serum


    Interested in more applications?

    Biotage offers a wide range of optimized application notes that you can access through our document hub!

    All application notes

    Recommended Products


    Supported Liquid Extraction plates and columns designed to provide high analyte recoveries, and clean, protein and phospholipid free extracts. Methods are easy to develop, and automation is simple.


    Protein & Phospholipid Removal products are  effective sample clean-up for LC-MS/MS analysis. Easily integrated into routine workflow, increasing productivity and reducing instrument downtime.

    BIOMARK002.173 - Vitamin test Evo Express ABN

    Eliminate conditioning and equilibration with EVOLUTE® EXPRESS load-wash-elute SPE. Robust, reliable SPE, giving ultra-pure extracts and high recoveries. Specifically developed for quantification by LC-MS/MS.

    PPM Manifolds
    Positive Pressure Processing

    Consistent, uniform flow of positive pressure to move both low and high viscosity liquids through plates and columns.


    Powerful, user friendly automation system for Supported Liquid Extraction (SLE), Solid Phase Extraction (SPE), Phospholipid Depletion (PLD) and Protein Precipitation (PPT) based methods, in plate or column formats.

    TurboVap® 96 Dual

    Designed for high throughput laboratories,  to provide efficient solvent evaporation in microplate formats.


    Selection of clinical sample preparation applications from Biotage.

    Method development chart, tips and tricks and useful insights to optimize your sample prep.
    Eliminate carryover between samples, and reduce the risk of false positive results. 

    A New, Streamlined Approach to Multiple Immunosuppressant Sample Preparation for LCMS analysis.

    Make your life easier. Simplify your workflow

    Automated sample preparation reduces errors, improves method robustness and frees up laboratory personnel for other tasks.

    Biotage evaporation systems are designed for fast sample evaporation and minimizing sample transfer.

    Discover the full range of sample preparation products from Biotage.