Forensic & Toxicology Sample Preparation

Urine Samples

Highlighted Applications

Analysis of drug panels in urine samples can be challenging, and the trend towards larger panels including multiple drug classes compounds the issues faced during method development.

Current Methodologies for Drugs of Abuse Urine Testing

This white paper explores different sample preparation techniques and methodologies for over 100 drugs in urine.

Scale Down Your Extraction. Enhance your Productivity

Extraction of 49 drugs from urine samples, with elution volume of just 30 µL. Microelution SPE can improve productivity without compromising analyte sensitivity or extract cleanliness.

Urine Hydrolysis: Does it matter how you do it?

Urine hydrolysis is performed to eliminate glucuronide drug metabolites before analysis, and it is key part of the sample preparation process. With today's advanced enzymes, hydrolysis can be much faster, and even be performed at room temperature. This poster illustrates how these enzymes can be used in a fully automated hydrolysis and clean up process.

Urine Sample Prep for GC-MS Analysis

GC-MS methods have been popular for analysis of drugs of abuse in urine for many years. But have you thought about updating your sample prep methods? Our application notes describe simple robust procedures for all the common drug classes:

Amphetamines
Barbiturates
Benzodiazepines
Cocaine and Metabolites
GHB
Phencyclidine (PCP)
Opiates
THC

Application Note Finder

Biotage offer a wide range of optimized application notes and our new Application Notes Finder is under construction. In the meantime, don't hesitate to contact us. Our team of application specialists is here to support you!

Recommended Products

ISOLUTE® SLE+

Supported Liquid Extraction plates and columns designed to provide high analyte recoveries, and clean, protein and phospholipid free extracts. Methods are easy to develop, and automation is simple.

Biotage® Mikro SPE

Excellent sample clean up while enhancing manual or automated sample preparation workflow and delivering reproducible, high sensitivity analytical results. For elution volumes as low as 20 µL.

ISOLUTE® HYDRO DME+

Efficient removal of matrix components and hydrolysis enzyme from urine and other biological fluid samples, using a simple pass through workflow. Available in columns and plates formats.

Positive Pressure Processing

Consistent, uniform flow of positive pressure to move both low and high viscosity liquids through plates and columns.

Extrahera™

Powerful, user friendly automation system for Supported Liquid Extraction (SLE), Solid Phase Extraction (SPE), Phospholipid Depletion (PLD) and Protein Precipitation (PPT) based methods, in plate or column formats.

96 Well Plate Evaporators

Designed for high throughput laboratories, to provide efficient solvent evaporation in microplate formats.

The revolution of microelution in solid phase extraction

Solid phase extraction is frequently used for sample clean up, trace enrichment, or a combination of both prior to analysis. But can solid phase extraction be an effective tool when bioanalysis demands higher sensitivity and reproducibility with decreasing sample volumes?

Resources

Get Started with Supported Liquid Extraction

Method development chart, tips and tricks and useful insights to optimize your sample prep.

Avoiding Cross Talk 96-well Based Sample Preparation

Eliminate carryover between samples, and reduce the risk of false positive results.

Watch the Webinar

Extraction of New and Emerging Drugs of Abuse Prior to LC-MS or GC-MS Analysis.

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Make your life easier. Simplify your workflow

Automated sample preparation reduces errors, improves method robustness and frees up laboratory personnel for other tasks.

Automation

Biotage evaporation systems are designed for fast sample evaporation and minimizing sample handling.