In the world of HPLC, loading capacity isn’t normally a concern as it is primarily an analytical technique. In the synthetic organic chemistry world, most purification is performed with silica gel where flash column purification methods are developed and loading capacity estimated from TLC data. However, when normal-phase flash does not work and reversed-phase flash is needed, the question of how to determine reversed-phase loading capacity comes up.
A blog post on the Flash Purification Blog provides some guidelines to help understand and determine reversed-phase flash chromatography loading capacity.
Ten Years with Environmental SPE Workflow - a User's Perspective
How St. John's University Accelerated their Cancer Research
Application Video: Extraction of Polyfluorinated Compounds in Water
Yes, You Can Add Biotage® Sfär Columns to Your Isolera™ System
Two New Applications Notes - Sample Preparation of a Drugs of Abuse Panel in Human Hair