Extraction of Phencyclidine from Meconium using ISOLUTE® HCX Columns
Part No: IST1019A
Issued year: 2011
File size: 0.14mb
File type: pdf
This method was developed for the extraction of phencyclidine from meconium for drugs ofabuse applications. The analyte has an ionisable amine group, which is exploited through cation exchange interactions. The pKa is approximately 8, so the compound is fully ionized at pH values of less than 6. The analyte also has significant non-polar characteristics, and both hydrophobic and ion exchange retention mechanisms are used to give a clean extract.
ISOLUTE, PCP, DOA, Varian Bond Elut Certify, UCT CleanScreen DAU
Application Notes
Clinical
Column
GC-MS
Meconium
Phencyclidine (PCP)