Part No: AN600Issued year: 2005File size: 0.08mbFile type: pdf
This Application Note reviews the use of ISOLUTE PPT+ plates for the isolation of drugs from biological fluids, including the method, recovery data and the impact of the filtrate’s cleanliness on analyte quantitation.
Part No: PPS321Issued year: 2013File size: 2.79mbFile type: pdf
Be sure you have your target compound the moment your purification is complete. The Isolera™
Dalton integrates the Biotage approach to flash chromatography with true compound identification
using mass detection.
Part No: AN079Issued year: 2014File size: 0.89mbFile type: pdf
Traditional RP-HPLC techniques not always critical because improvements in solid-phase peptide synthesis techniques over the years (microwave heating and ChemMatrix® solid phase supports) have reduced the burden on downstream purification steps. Mass directed flash purification can be a viable alternative to more expensive (and lower capacity) semi- or prep-scale RP-HPLC methods.
Isolera Dalton identifies compounds by mass in real time during flash separation, leading to greater confidence in purification, higher purity, greater recovery, and a significant saving in time. Reduce or eliminate the need for time consuming off-line mass analysis during development programs, increase throughput and effectiveness for both chemists and analytical groups.
The Isolera ELSD (evaporative light-scattering detector) is a universal detector designed for use with Isolera flash purification systems when purifying organic compounds that
are undetectable UV or visible light. Flash chromatography with detection and fractionation is now possible when purifying carbohydrates, steroids, lipids, terpenes and other UVtransparent compounds.
Part No: TN/UG-0028.0509Issued year: 2009File size: 0.39mbFile type: pdf
The Isolera leak detection system is designed with safety in
mind. Unlike vapor sensing devices with unreliable solvent
vapor sensitivity, the Isolera leak detector’s sensitive,
solvent-resistant refractive index (RI) monitor rapidly
signals the Isolera flash system to stop pumping if any
liquid, volatile or non-volatile, is detected thus protecting
the chemist, system, and lab from potential hazards.
Part No: TN-0024.0210 (2)Issued year: 2010File size: 0.61mbFile type: pdf
TheBiotage Isolera™LS development-scale flash purification
systemdramatically shortens large-scale purification run-times
with flow rates of 50-500mL/minute. Simply select or create a
method, load your sample, and run – it’s that easy. New
advanced features include: solvent-savingGradientOptimization
(GO), the ability to collect fractions on two separatewavelengths,
use of up to four solvents in a single gradient and add a third