Part No: PPS377.V.1Issued year: 2016File size: 1.13mbFile type: pdf
Biotage® Metal Scavenging Toolkit is an essential tool that can enable you to quickly and efficiently find the right metal scavenger for your application. It contains protocols, guidance and recommendations for working in batch mode or passing solutions through a fixed bed, this all in one kit showcases the metal scavengers and provides practical information on how to use the metal scavengers in your application for the best results.
Part No: PPS458Issued year: 2017File size: 1.04mbFile type: pdf
On Aug 30, 2017 a scientific literature search for the keywords Biotage AND peptide
was performed by Biotage personnel. The search identified 5380 peer-reviewed
publications from the global community, excluding patents and simple citations.
Below are approximately 100 titles illustrating the breadth and depth of research in
which Biotage tools are utilized.
Part No: PPS381Issued year: 2015File size: 1.07mbFile type: pdf
The versatility of Biotage® V-10 enables evaporation of single samples (up to 12 mL) or large pooled volumes using V-10 pumps (syringe or peristaltic). Adding the automated vial loading/changing carousel enables unattended evaporation of up to 16 samples.
Part No: PPS304Issued year: 2012File size: 1.27mbFile type: pdf
Biotage ZIP Sphere delivers better purification and improved throughput than comparable flash cartridges. The silica surface area has been increased by 40%, meaning higher loading capacity, improved separations, and reduced purification time and solvent use.
Part No: 414127-AIssued year: 2014File size: 1.49mbFile type: pdf
Introduction to the Detector, Site Requirements and Specifications, Installing the Detector, Using the Detector, Optimizing Performance, Troubleshooting and Diagnostics, Error Information, Maintenance, and Parts and Materials for Maintenance.
Part No: 414158-JIssued year: 2017File size: 5.82mbFile type: pdf
The document is for systems with the Extrahera 1.5.4 software installed.
Contents: System Overview; Power Failure; Manage Solvents, Sample Types, Plates, Racks, and Pipette Tips; Set Up a Method; Run Single or Multiple Methods; Maintenance; Manual Control; Troubleshooting; Switch Between 24, 48, and 96 Format; General Information
Part No: UI332Issued year: 2015File size: 0.15mbFile type: pdf
During the preventive maintenance visit, the system is given a thorough strip down, service, reassembly and performance/function test to help ensure that it will remain in good working order for the following year.
Part No: 414159-DIssued year: 2017File size: 2.09mbFile type: pdf
Translated versions of the Safety chapter available in the Biotage® Extrahera™ Installation and Safety document (P/N 414157). Languages: Chinese, Danish, Dutch, Finnish, French, German, Greek, Italian, Japanese, Portuguese, Spanish, and Swedish.
Part No: 02140-AIssued year: 2014File size: 3.76mbFile type: pdf
INTRODUCING BIOTAGE® FLASH 150I, COMPONENTS OF BIOTAGE® FLASH 150I, INSTALLATION/GETTING STARTED, HOW TO USE BIOTAGE® FLASH 150I, TROUBLESHOOTING, PRICE LIST AND ORDERING INFORMATION, OPTIMIZING FLASH SEPARATIONS, FLASH CHROMATOGRAPHY WORKBOOK, and CE INFORMATON ADDENDUM.
Part No: 355977-FIssued year: 2014File size: 1.32mbFile type: pdf
Translated versions of the Safety chapter available in the Biotage® Initiator Installation and Safety document (P/N 355976). Languages: Danish, Dutch, Finnish, French, German, Italian, Japanese, Spanish, and Swedish.
Part No: 355977-GIssued year: 2015File size: 2.37mbFile type: pdf
Translated versions of the Safety chapter available in the Biotage® Initiator+ Installation and Safety document (P/N 355976). Languages: Danish, Dutch, Finnish, French, German, Italian, Japanese, Spanish, and Swedish.
Microwave irradiation is still the most effective solution for providing a fast, precise and efficient heating method for synthesizing peptides, peptoids, PNA and peptidomimetics with higher purity and yield compared to conventional synthesis methods. The Biotage® Initiator+ Alstra is a fully automated microwave peptide synthesizer with built in flexibility for both small and large scale synthesis.
Part No: PPS320.v.1Issued year: 2014File size: 0.98mbFile type: pdf
Biotage® Initiator+ Alstra™ is a fully automated, single channel, programmable microwave peptide
synthesizer for Fmoc-solid phase peptide synthesis. This instrument now comes with the Alstra 1.1
software upgrade that introduces new functionality such as Branches, Preactivation and “Edit on
the fly”, and options for UV monitoring and MAOS (organic synthesis) capability.
Part No: PPS390.V.1Issued year: 2016File size: 1.05mbFile type: pdf
Biotage® MP-Borohydride is a macroporous, solid-supported borohydride that is a solid-supported equivalent of tetraalkylammonium borohydride. The bound borohydride is a versatile reducing agent used for the reduction of carbonyl
compounds and imines, and the reductive amination of aldehydes and ketones.
Part No: PPS392.V.2Issued year: 2016File size: 1.1mbFile type: pdf
Biotage® MP-Cyanoborohydride is a macroporous polymer-supported cyanoborohydride which is a solid-supported equivalent of tetraalkylammonium cyanoborohydride. The bound cyanoborohydride can be utilized as a versatile reducing agent for the reductive amination of carbonyl compounds and reduction of imines.
Part No: PPS391.V.1Issued year: 2016File size: 1.79mbFile type: pdf
Biotage® MP-Triacetoxyborohydryde is a macroporous polystyrene-supported equivalent of tetraalkylammonium triacetoxyborohydride. MP-Triacetoxyborohydride has primary applications in the reductive amination of aldehydes and ketones under neutral or mildly acidic reaction conditions.
Part No: PPS404.V.1Issued year: 2016File size: 1.41mbFile type: pdf
PS-Benzaldehyde is the resin-bound equivalent of benzaldehyde. This resin is useful for scavenging various nucleophiles, including primary amines (selectively compared with secondary amines), hydrazines and also carbon-based nucleophiles such as Meldrum’s acid and organometallics.
Part No: PPS402.V.1Issued year: 2016File size: 0.95mbFile type: pdf
PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. PS-Carbodiimide may also be used for the synthesis of pentafluorophenyl (PFP) activated esters (Table 3) and N-hydroxysuccinimidyl esters
Part No: PPS393.V.1Issued year: 2016File size: 0.98mbFile type: pdf
Biotage® PS-HOBt(HL) is a sulfonamide-linked, polymersupported
equivalent of 1-hydroxybenzotriazole (HOBt). PS-HOBt(HL) is used to generate bound HOBt active esters, which can either be made and used in situ, or isolated and stored as stable intermediates.
Part No: PPS400.V.1Issued year: 2016File size: 1.3mbFile type: pdf
Biotage®PS-Isocyanate is a 1% cross-linked poly(styreneco-divinylbenzene) which has pendent benzylisocyanate functionality. The resin can readily scavenge excess nucleophiles, which are often used to drive reactions to completion.
Part No: PPS401.V.1Issued year: 2016File size: 2.11mbFile type: pdf
PS-PPh3-Pd resin is a polystyrene-supported equivalent of the small molecule catalyst tetrakis(triphenylphosphine) palladium(0) [Pd(Ph3P)4]. The primary application for the resin is as a catalyst for Suzuki-Miyaura coupling reactions between arylboronic acids and aryl halides.
Part No: PPS382.V.1Issued year: 2016File size: 1.63mbFile type: pdf
Biotage® PS-TBD is a polymer-supported base, which applications are Alkylation of phenols and amines; esterification of carboxylic acids using alkyl halides; alkylation of activated methylene compounds; dehalogenation of organic halides; high throughput synthesis of aryl triflates and aryl nonaflates; Williamson ether synthesis
Part No: PPS389.V.1Issued year: 2016File size: 2.64mbFile type: pdf
Biotage® PS-Triphenylphosphine is a diphenylphosphinated polystyrene resin that is a solid-supported equivalent of triphenylphosphine. The resin can readily convert alcohols or carboxylic acids to the corresponding chlorides or acid chlorides in carbon tetrachloride.
Part No: PPS437Issued year: 2016File size: 0.19mbFile type: pdf
Biotage® SNAP Bio flash cartridges were developed with a small
particle size (20 μm) and large pore size (300 Å) to provide
increased resolution and effective separation of complex
peptide mixtures. Depending on the quality of the peptides
synthesized, flash chromatography can be used either as the
sole method of purification or as a front end clean-up prior to
SNAP Bio offers close to prep-HPLC performance in a flash
format at a fraction of the cost
Part No: TN-0016.0108Issued year: 2008File size: 0.4mbFile type: pdf
Biotage SNAP cartridges can be used on any flash system.
The easy-to-use Luer-lok® connections do not need a
compression module to operate at 100 psi. Made from USP
Class VI materials, Biotage SNAP cartridges offer 7 types of
loading techniques including 3 internal dry loading options.
Packed to provide the highest plate count of any 50μm particle
cartridge on the market, SNAP provides increased loading
capacity and better compound separations.
Part No: TN-0025.0508Issued year: 2008File size: 0.35mbFile type: pdf
SNAP KP-NH cartridges contain amine functionalized silica.
This optimized media shields synthetic organic amines from
acidic silanols providing improved selectivity, peak shape,
purity and yield (Figure 1). Unlike traditional silica and 1°
amine (propyl amine) bonded silica, KP-NH doesn’t require the
use of chlorinated solvents or amine additives.
Part No: Issued year: 2009File size: 0.06mbFile type: pdf
SNAP flash cartridges provide several sample load options including both internal and external liquid and dry loading. This
Quick-start Guide provides sample load guidelines and loading technique suggestions, which should help you get the most
from your SNAP cartridges.
Part No: Issued year: 2008File size: 0.09mbFile type: pdf
SNAP flash cartridges provide several sample load options including both internal and
external liquid and dry loading. This Quick Start Guide provides sample load guidelines and
loading technique suggestions, which should help you get the most from your SNAP
Part No: TN-SNAP-RPC-0211Issued year: 2011File size: 1.11mbFile type: pdf
Reversed-phase flash chromatography is a very popular
purification technique using a non-polar stationary phase.
Main application areas include separation of polar, ionizable
and highly lipophilic compounds which cannot easily be
separated by normal-phase techniques.
Part No: TN-0032.0112Issued year: 2012File size: 0.75mbFile type: pdf
Precision engineered Biotage SNAP Ultra cartridges deliver double
the purification capacity utilizing small particle spherical silica with
an 40% increase in surface area. This proprietary silica reduces
peak width and provides higher concentration fractions with less
Part No: PPS447Issued year: 2017File size: 0.96mbFile type: pdf
Biotage® SPE Dry 96 and SPE Dry 96 Dual Sample Concentrators are suitable for evaporation of microplate samples across a broad range of formats. By delivering heated gas above and below each well, SPE Dry 96 systems dry samples quickly maintaining tight temperature control at user selected settings. Designed for high throughput sample processing,
SPE Dry systems have simple front panel controls and use removable gas delivery assemblies for fast adjusting and cleaning.
Part No: PPS425Issued year: 2016File size: 2.58mbFile type: pdf
Biotage® V-10 Touch rapidly dries samples dissolved in both aqueous and organic solvents. Combined with the Gilson liquid handling robot automatically transfers your purified samples to V-10 Touch for sequential automated evaporation. This brochure lists all evaporation vials, adapters and accessories.
Part No: UI303Issued year: 2013File size: 4.69mbFile type: pdf
The Biotage® VacMaster™ is a state-of-the-art sample processing station. It incorporates innovative design features that make simultaneously processing multiple samples easier than ever before. For scientists working with biological fluids, these features and operating procedures provide a safe system.
Part No: UI327Issued year: 2015File size: 1.4mbFile type: pdf
Biotage® ACT Plate Adapter (patent pending) is designed to reduce or eliminate the occurrence of well-to-well cross contamination (cross talk) during extract evaporation, and fits on top of the 96-well collection plate during evaporation.
Part No: P137Issued year: 2015File size: 0.37mbFile type: pdf
This poster examines various factors in the development and optimisation of a SPE-LC-MS/MS method for extraction of catecholamines from plasma.
The final method utilizes EVOLUTE EXPRESS WCX plates in either standard SPE or fast Load-wash-elute modes, and incorporates a series of wash steps to optimise analytical sensitivity. Low elution volumes mean no evaporation step is required, and LLOQ is 20mg/mL or lower for each of the analytes.
Part No: P137v2Issued year: 2016File size: 0.39mbFile type: pdf
This poster investigates various parts of the SPE method development process to develop a highly sensitive LC-MS/MS method for analysis of catecholamines (epinephrine, norepinephrine, dopamine).
A number of steps are optimized to improve sensitivity of the
analytes. This includes reducing the buffer strength in the mobile
phase, reducing the buffer strength of washes, careful pH control
throughout the extraction, avoiding an evaporation step and
incorporating IPA in the reconstitution solvent.
Part No: Issued year: 2012File size: 0.11mbFile type: pdf
The following organization’s Quality Management System has been assessed and registered by Intertek Certification AB as conforming to the requirements of: SS-EN ISO 9001:2008
The Quality Management System is applicable to: Development and production of specialty polymers (MIPs and NIPs) for industrial separations and laboratory trace analysis.