Part No: AN909.V.1Issued year: 2014File size: 1.37mbFile type: pdf
Cyclosporine is an immunosuppressant used in organ transplants to overcome rejection. Following the transplant of a heart, liver, kidney or lung, a patient must be regularly tested for the rest of their lives. Blood testing intervals vary from 1 month to 6 months and this rapid reference method is ideal for batch tests with the advantage of no metabolite interfer-ence which is always found in immunological methods.
Part No: AN908.V.1Issued year: 2014File size: 1.33mbFile type: pdf
The removal of interferences and sample concentration are
essential steps in trace level detection of pesticides, sheep
dips, herbicides and PCBs in river water, wastewaters and
trade effluents. The following methods were developed by
the Environment Agency National Laboratory Service facility
at Nottingham using the Biotage RapidTrace for automated
solid phase extraction and the TurboVap II for evaporation.
The procedures are UKAS accredited and can reach detection
limits of 0.001 ug/Litre for some compounds.
Part No: AN904.V1Issued year: 2014File size: 1.33mbFile type: pdf
EPA methods 8260 & 8270 cover the analysis of polychlorinated
dibenzo-p-dioxins and polychlorinated dibenzofurans
in ground & surface waters. This also now includes
1,4-dioxane and PCBs. This application note will focus on
the automated SPE of the sample rather than the detection
which usually involves GCMS or LCMS. NB The columns
and reagents used for soils and sediment analysis differ to
ground water extraction.
Part No: AN905Issued year: 2010File size: 0.25mbFile type: pdf
The extraction and segregation of Organic compounds from core samples taken from marine sediments is used to predict climate conditions, reconstruct sea temperatures and identify the type of vegetation from the C3 ( Temperate cli-mate) and C4 ( Tropical Climate) isotopic mass spectroscopy ratio analysis.
Part No: AN906.V.1Issued year: 2014File size: 1.29mbFile type: pdf
With the widespread clinical use of antidepressant drugs comes the need to accurately measure therapeutic lev-els to determine proper dosage, as well as check for toxic levels and patient compliance. More and more laboratories are shifting their therapeutic drug monitor-ing from liquid extraction to solid phase extraction. A large clinical laboratory has automated the process of extracting these drugs from serum using the RapidTrace SPE Workstation.
Part No: AN002-HORIssued year: File size: 0.94mbFile type: pdf
This study shows that the Biotage® 4790 Automated Extractor system, along with the Atlantic™ DVB disk, the DryDisk® separation membrane, and the DryVap® Concentrator System can be successfully used to analyze for Nonyl Phenol and Bisphenyl A in water samples. This sample preparation process is fully automated, requiring minimal human intervention, and allowing for reductions in sample processing costs.
Part No: RP-DS-04Issued year: 2010File size: 0.19mbFile type: pdf
When analyzing human urine for drugs of abuse, one of the most common tests is for the cocaine metabolite Benzoylecgonine (BZE). A contract laboratory has automated this labor intensive procedure using the RapidTrace.
Part No: P101Issued year: 2014File size: 0.4mbFile type: pdf
Using the TLC to step gradient is simple and fast requiring only a minute or so to enter the data into the Isolera and create the method. The methods are scalable to larger cartridges increasing purification savings even more.
Part No: AN093.v2Issued year: 2014File size: 0.67mbFile type: pdf
We demonstrate the capability of the Biotage® Initiator+ Alstra™ microwave peptide synthesizer to fully automate the on-resin synthesis of cyclic peptides with examples showing disulfide bridge formation and side-chain to side-chain cyclization respectively.
Part No: P175Issued year: 2018File size: 2.14mbFile type: pdf
This poster presents a method for detection of approximately 100 drugs and metabolites in urine using mixed-mode polymeric cation exchange solid phase extraction (SPE).
Four different glucuronidase enzymes and several incubation times and temperatures were evaluated to determine optimum hydrolysis conditions for seven commonly detected glucuronide metabolites. Samples were subjected to offline hydrolysis and SPE (EVOLUTE® EXPRESS CX, Biotage, Charlotte, NC) and results compared to an SPE plate that incorporates in-well hydrolysis (EVOLUTE HYDRO CX, Biotage).
MSACL 2018, Palm Springs, CA
This brochure presents the extensive range of instrumentation for flash purification from Biotage. To complement these products Biotage also offers a complete range of flash consumables, including columns in a variety of sizes packed with irregular and spherical silica, making Biotage your one-stop partner for your flash purification needs.
Keywords: Isolera™ Dalton, Isolera™ Spektra, 10 Isolera™ Spektra One and Four, Isolera™ Spektra LS (Large Scale), Isolera™ Prime, Isolera™ ELSD-1080, Biotage® Flash 75/150, Biotage® Flash 400
Part No: BiotHR1Issued year: 2017File size: 0.15mbFile type: pdf
This statement sets out Biotage’s actions to understand all potential modern slavery risks related to its business and to put in place steps that aim at reducing the risk of slavery or human trafficking occurring within in its own business and its supply chains. This statement relates to actions and activities during the financial year 1 Jan 2016 to 31 December 2016.
Part No: PPS377.V.1Issued year: 2016File size: 1.13mbFile type: pdf
Biotage® Metal Scavenging Toolkit is an essential tool that can enable you to quickly and efficiently find the right metal scavenger for your application. It contains protocols, guidance and recommendations for working in batch mode or passing solutions through a fixed bed, this all in one kit showcases the metal scavengers and provides practical information on how to use the metal scavengers in your application for the best results.
Part No: PPS458Issued year: 2017File size: 1.04mbFile type: pdf
On Aug 30, 2017 a scientific literature search for the keywords Biotage AND peptide
was performed by Biotage personnel. The search identified 5380 peer-reviewed
publications from the global community, excluding patents and simple citations.
Below are approximately 100 titles illustrating the breadth and depth of research in
which Biotage tools are utilized.
Part No: PPS381Issued year: 2015File size: 1.07mbFile type: pdf
The versatility of Biotage® V-10 enables evaporation of single samples (up to 12 mL) or large pooled volumes using V-10 pumps (syringe or peristaltic). Adding the automated vial loading/changing carousel enables unattended evaporation of up to 16 samples.
Part No: PPS304Issued year: 2012File size: 1.27mbFile type: pdf
Biotage ZIP Sphere delivers better purification and improved throughput than comparable flash cartridges. The silica surface area has been increased by 40%, meaning higher loading capacity, improved separations, and reduced purification time and solvent use.
Part No: 414127-AIssued year: 2014File size: 1.49mbFile type: pdf
Introduction to the Detector, Site Requirements and Specifications, Installing the Detector, Using the Detector, Optimizing Performance, Troubleshooting and Diagnostics, Error Information, Maintenance, and Parts and Materials for Maintenance.
Part No: 414158-JIssued year: 2017File size: 5.82mbFile type: pdf
The document is for systems with the Extrahera 1.5.4 software installed.
Contents: System Overview; Power Failure; Manage Solvents, Sample Types, Plates, Racks, and Pipette Tips; Set Up a Method; Run Single or Multiple Methods; Maintenance; Manual Control; Troubleshooting; Switch Between 24, 48, and 96 Format; General Information
Part No: 414159-DIssued year: 2017File size: 2.09mbFile type: pdf
Translated versions of the Safety chapter available in the Biotage® Extrahera™ Installation and Safety document (P/N 414157). Languages: Chinese, Danish, Dutch, Finnish, French, German, Greek, Italian, Japanese, Portuguese, Spanish, and Swedish.
Part No: 355977-FIssued year: 2014File size: 1.32mbFile type: pdf
Translated versions of the Safety chapter available in the Biotage® Initiator Installation and Safety document (P/N 355976). Languages: Danish, Dutch, Finnish, French, German, Italian, Japanese, Spanish, and Swedish.
Part No: 355977-HIssued year: 2017File size: 2.38mbFile type: pdf
Translated versions of the Safety chapter available in the Biotage® Initiator+ Installation and Safety document (P/N 355976). Languages: Danish, Dutch, Finnish, French, German, Italian, Japanese, Spanish, and Swedish.
Microwave irradiation is still the most effective solution for providing a fast, precise and efficient heating method for synthesizing peptides, peptoids, PNA and peptidomimetics with higher purity and yield compared to conventional synthesis methods. The Biotage® Initiator+ Alstra is a fully automated microwave peptide synthesizer with built in flexibility for both small and large scale synthesis.
Part No: PPS320.v.1Issued year: 2014File size: 0.98mbFile type: pdf
Biotage® Initiator+ Alstra™ is a fully automated, single channel, programmable microwave peptide
synthesizer for Fmoc-solid phase peptide synthesis. This instrument now comes with the Alstra 1.1
software upgrade that introduces new functionality such as Branches, Preactivation and “Edit on
the fly”, and options for UV monitoring and MAOS (organic synthesis) capability.
Part No: PPS390.V.1Issued year: 2016File size: 1.05mbFile type: pdf
Biotage® MP-Borohydride is a macroporous, solid-supported borohydride that is a solid-supported equivalent of tetraalkylammonium borohydride. The bound borohydride is a versatile reducing agent used for the reduction of carbonyl
compounds and imines, and the reductive amination of aldehydes and ketones.
Part No: PPS392.V.2Issued year: 2016File size: 1.1mbFile type: pdf
Biotage® MP-Cyanoborohydride is a macroporous polymer-supported cyanoborohydride which is a solid-supported equivalent of tetraalkylammonium cyanoborohydride. The bound cyanoborohydride can be utilized as a versatile reducing agent for the reductive amination of carbonyl compounds and reduction of imines.
Part No: PPS391.V.1Issued year: 2016File size: 1.79mbFile type: pdf
Biotage® MP-Triacetoxyborohydryde is a macroporous polystyrene-supported equivalent of tetraalkylammonium triacetoxyborohydride. MP-Triacetoxyborohydride has primary applications in the reductive amination of aldehydes and ketones under neutral or mildly acidic reaction conditions.
Part No: PPS404.V.1Issued year: 2016File size: 1.41mbFile type: pdf
PS-Benzaldehyde is the resin-bound equivalent of benzaldehyde. This resin is useful for scavenging various nucleophiles, including primary amines (selectively compared with secondary amines), hydrazines and also carbon-based nucleophiles such as Meldrum’s acid and organometallics.
Part No: PPS402.V.1Issued year: 2016File size: 0.95mbFile type: pdf
PS-Carbodiimide is a neutral, bound carbodiimide that can be used for the synthesis of amides and esters. PS-Carbodiimide may also be used for the synthesis of pentafluorophenyl (PFP) activated esters (Table 3) and N-hydroxysuccinimidyl esters
Part No: PPS393.V.1Issued year: 2016File size: 0.98mbFile type: pdf
Biotage® PS-HOBt(HL) is a sulfonamide-linked, polymersupported
equivalent of 1-hydroxybenzotriazole (HOBt). PS-HOBt(HL) is used to generate bound HOBt active esters, which can either be made and used in situ, or isolated and stored as stable intermediates.
Part No: PPS400.V.1Issued year: 2016File size: 1.3mbFile type: pdf
Biotage®PS-Isocyanate is a 1% cross-linked poly(styreneco-divinylbenzene) which has pendent benzylisocyanate functionality. The resin can readily scavenge excess nucleophiles, which are often used to drive reactions to completion.