The global need for custom and synthetic therapeutic peptides is growing, as academic researchers and the pharmaceutical and biotech industries renew their interest in peptide-based drug discovery. As researchers require higher quality peptides in ever greater quantities and complexity, the need for reliable and innovative tools that offer greater productivity and increased performance is also growing. Biotage is dedicated to meeting these needs and committed to developing the tools needed by the global peptide community for peptide synthesis and purification.
Part No: PPS439Issued year: 2017File size: 0.7mbFile type: pdf
Dr. Andrew Jamieson leads a team of peptide chemists at the University of Glasgow, where
they synthesize complex molecules for chemical biology applications. An important tool that
contributes to their success has been Biotage® Initiator+ Alstra™ microwave peptide synthesizer,
and they are even breaking the dogma that only HPLC can be used for peptide purification, by
using cutting edge reversed phase flash purification techniques provided by Biotage.
Part No: I-Prime_ZIP_TN-30.1011Issued year: 2011File size: 0.3mbFile type: pdf
Biotage ZIP flash chromatography cartridges are engineered to meet the needs of chemists requiring high performance and consistency from a purification cartridge at a value price to reduce purification costs.
Isolera Prime flash purification system.
Part No: P023Issued year: 2008File size: 0.37mbFile type: pdf
Sample preparation is an essential technique prior to LC-MS/MS analysis of drugs in biological fluid samples to remove unwanted matrix components. These matrix components, particularly salts, proteins and phospholipids, can lead to ion suppression resulting in inaccurate quantitation and reduced detection limits. Resin-based mixed-mode cation exchange SPE sorbents are widely used for the extraction of basic compounds from biological fluids. The dual retention mechanism allows a two stage interference wash protocol, which results in extremely
clean extracts. This poster investigates the performance of EVOLUTE™ CX for overall ion suppression, then individual matrix components examined in terms of protein and phospholipid removal.
Part No: Issued year: 2005File size: 0.44mbFile type: pdf
PS-HOBt(HL) is a higher loading version (0.9 – 1.4 mmol/g) of a sulfonamide-linked,
resin-bound equivalent of 1-hydroxybenzotriazole (HOBt). PS-HOBt(HL) can be used as an effective activating reagent for transfer of protecting groups, e.g., Fmoc and Cbz, to amines.
Part No: Issued year: 2007File size: 0.26mbFile type: pdf
PS-TBD is a polymer-supported base, which
consists of a bicyclic guanidine moiety (1,5,7-
triazabicyclo[4.4.0]dec-5-ene) anchored on
polystyrene. PS-TBD is a stronger polymersupported
base than the PS-DIEA and PS-NMM
resins, which are bound tertiary amines that are
used in organic synthesis and reagent
scavenging. Published applications of PS-TBD
include alkylation of phenolsi and amines;ii
esterification of carboxylic acids using alkyl
halides; alkylation of activated methylene
compounds; de-halogenation of organic
halides;iii high throughput synthesis of aryl
triflates and aryl nonaflates,iv and the
regioselective synthesis of lysophospholipids.
Part No: Issued year: 2005File size: 1.52mbFile type: pdf
PS-DEAM is a polystyrene-bound diethanolamine, which is a resin-bound equivalent of the tridentate (N, O, O) N-alkyldiethanolamine ligand. PS-DEAM is an effective scavenger for a variety of oxophilic organometallic and inorganic complexes. The resin can be used to quench reactions and remove metallic reagents, catalysts or byproducts, allowing the purified product to be isolated by filtration. Boronic acids are scavenged by PS-DEAM. This has been exploited in the purification of Suzuki reactions through the removal of excess boronic acid and coupling byproducts.
Part No: Issued year: 2005File size: 0.38mbFile type: pdf
MP-Borohydride is a macroporous, polystyrene-bound borohydride, that is a resin-bound equivalent of tetraalkylammonium borohydride. The bound borohydride is a versatile reducing agent1,2,3 used for the reduction of carbonyl compounds and imines, and the reductive amination of aldehydes and ketones. The resin, in conjunction with some transition metal salts, can also be used for a number of other important reductive applications, such as reduction of oximes,
azides and alkyl halides. The reduced products are isolated by simple filtration away from the resin.
Part No: AN800Issued year: 2003File size: 0.05mbFile type: pdf
The automated Advantage Series™ 3400 ChemCorder™ workflow replicator was used to record all the manual operations a chemist performs during a highly exothermic chemical reaction (Figure 1).Before the experiment was initiated, the ChemCorder replicator was put in record mode.All steps of the experiment were accurately recorded, including any comments and observations. Once completed the ChemCorder replicator produced a report and recipe file of the chemistry. This recipe file was used to accurately and automatically repeat the reaction. Alternatively, the file could have been modified to produce a new recipe based on the recorded chemistry
Biotage® PRESSURE+ manifolds deliver positive pressure, parallel processing for 96 well plates,
1 mL 3 mL and 6 mL column formats. The systems utilize a consistent, uniform flow of positive pressure to move both low and high viscosity liquids through SPE plates and columns. Each port of the PRESSURE+ manifold independently maintains constant pressure, increasing the overall reproducibility of analyte recoveries. This unique design allows for partially populated racks to be used without sacrificing extraction efficiency.
Part No: Issued year: 2005File size: 0.3mbFile type: pdf
PS-DIEA is a high loading tertiary amine base which is a resin-bound equivalent of diisopropylethylamine. PSDIEA is useful in applications requiring a tertiary amine
base, where the resin-bound ammonium salt byproducts are readily separated by filtration.1 Synthesis of amides, sulfonamides and carbamates can be effected using filtration as the only purification step when PSDIEA is used in conjunction with PS-Trisamine or PSIsocyanate
as scavenger resins.
Part No: Issued year: 2005File size: 0.43mbFile type: pdf
PS-DMAP is a polymer-bound equivalent of dimethylaminopyridine (DMAP) which may be used as a catalyst for acylation and related reactions. PS-DMAP has a loading of 1.4 mmol/g based on nitrogen analysis. Typical catalysis conditions require 10 - 20 mol% relative to the nucleophile. Catalytic PS-DMAP accelerates the acylation of sluggish nucleophiles, e.g. tertiary alcohols.