Part No: P012Issued year: 2006File size: 0.22mbFile type: pdf
The use of palladium-catalysts in the synthesis of fine chemicals, pharmaceutical intermediates and active pharmaceutical ingredients (APIs) has become quite common in the last few decades. The number of palladiumcatalyzed reactions (both achiral and chiral) available to chemists has provided access to more complex structures in fewer steps and with less waste. An unfortunate side effect of using palladium is the potential for palladiumcontaining impurities to remain in the desired compound after isolation. This is an especially significant problem for the pharmaceutical industry since there is a low limit for heavy metal impurities allowed in the drug substance.
Part No: AN072.v2Issued year: 2013File size: 0.39mbFile type: pdf
Here we present the separation capabilities of a new type of designed adsorbent, RENSA® Boronate. This new resin has affinity for diols and α-hydroxycarboxylic acids and is able to extract those target compounds with high efficiency and selectivity.
Part No: Issued year: 2010File size: 0.26mbFile type: pdf
• Solid-Phase Peptide Synthesis (SPPS) is still often
faced with difficulties in the assembly of long and
‘difficult’ sequences, e.g. due to aggregation and
steric hindrance giving rise to incomplete reactions.
These problems have only partly been solved by
new coupling reagents and solid supports.
• Precise microwave heating has emerged as one
new parameter for SPPS, in addition to coupling
reagents, resins, solvents etc.
Part No: AN091Issued year: 2014File size: 0.63mbFile type: pdf
Three protected carbohydrate derivatives, 1,2:5,6-Di-O-Isopropylidene-
α-D-glucofuranose, Methyl 4,6-O-Benzylidene-α-D-glucopyranose, and
1,2-O-Isopropylidene-α-D-glucofuranose were successfully separated and
detected, using a Biotage® SNAP KP-Sil cartridge on a Biotage Isolera™ system
with the Biotage® Evaporative Light-Scattering Detector (ELSD) attached.
Part No: AN089Issued year: 2014File size: 0.68mbFile type: pdf
Three sterols, (+)-dihydrocholesterol, β-estradiol-3-benzoate, and
β-estradiol were successfully separated, detected, and isolated using a
Biotage® SNAP KP-Sil cartridge attached to a Biotage Isolera™ One system connected to Biotage® Evaporative Light-Scattering Detector (ELSD).
Part No: Issued year: 2007File size: 3.19mbFile type: pdf
Biotage bietet ein umfassendes Jahresservice-Konzept, inhaltlich aller Ersatzteile, Arbeit vor Ort und empfohlener vorbeugender Wartung. Holen Sie sich den Prioritätsstatus für alle Service-Anrufe durch spezialisierte Außendiensttechniker von Biotage und mit
Original-Biotage-Ersatzteilen (wesentlich zur Aufrechterhaltung der optimalsten Geräteleistung).
Part No: Issued year: 2007File size: 0.05mbFile type: pdf
PS-TsNHNH2 and ISOLUTE® Si-TsNHNH2 are solid supported equivalents of p-toluenesulfonyl hydrazide. These reagents are both excellent scavengers for aldehydes and ketones and are generally used in threefold excess with respect to the limiting carbonyl species. A catalytic amount of acetic acid (5-10%) may be required for ketones, hindered substrates or for scavenging in certain solvents (e.g. DMF).
Part No: P022Issued year: 2008File size: 0.09mbFile type: pdf
Microwave-assisted esterification of protected amino acid derivatives was performed using alkyl halides and polystyrene supported TBD1,2 (Fig. 1) as base. The preferred solvents were THF or acetonitrile. The products were obtained in good yields and high purity. Short reaction time, 10 minutes, and easy work-up, filtration and evaporation, constituted a convenient procedure. Benzyl, allyl, phenacyl, and alkyl esters, all important and commonly used derivatives in peptide synthesis, were synthesised.
Part No: P152Issued year: 2016File size: 0.49mbFile type: pdf
This poster describes a method for the simultaneous extraction (using EVOLUTE EXPRESS WCX) and analysis of plasma catecholamines and metanephrines. A highly sensitive, linear and rugged assay was developed, and automated using the Biotage Extrahera sample preparation processing system.
MSACL EU 2016
Part No: AN755Issued year: 2012File size: 1.03mbFile type: pdf
Ethyl glucuronide (EtG) and ethyl sulphate (EtS) are specific metabolites formed within the body after the ingestion of alcohol. In forensic toxicology, when tested together they provide more specific evidence of alcohol intake. This application note demonstrates the simultaneous extraction of both EtG and EtS in the same assay and represents further optimization of AN718 which showed single EtG extraction without EtS. Recoveries for EtG range from 90-105% and 80-103% for EtS across two formats of EVOLUTE AX columns with RSDs <10%. The LOQ is 10 ng/mL for EtG and 2 ng/mL for EtS across both EVOLUTE AX formats.
EVOLUTE AX, EVOLUTE, EtS, EtG, Ethyl Glucuronide, Ethyl Sulfate, SPE, Anion Excange, Urine, OASIS, Waters, Polymeric, Polmers,
Part No: AN098Issued year: 2014File size: 0.81mbFile type: pdf
To demonstrate the cost savings by employing small μmol scale automated solid phase peptide synthesis through robot liquid handling of reagents with accurate dispensing of small volumes, a 10-mer antimicrobial peptide was synthesized.
Part No: Issued year: 2008File size: 0.13mbFile type: pdf
The adapter kit contains a pre-assembled stand, spacer and
connecting tubing; everything required to allow the use of
SNAP 340g cartridges on flash purification systems that utilize
Luer tubing connections such as, Isco Companion and Analogix
Part No: install_snap_25.zipIssued year: 2012File size: 0mbFile type: zip
7742_install_snap_25.zip. SPX 25 g SNAP cartridge installation.
The system already has the SNAP 10 g, 50 g, 100 g and 340 g cartridges installed
(only the SNAP 25 g needs to be installed)
Part No: install_snap_full.zipIssued year: 2012File size: 0mbFile type: zip
install_snap_full.zip. SNAP Software Update for Biotage® SP Systems. SPX FULL SNAP cartridge installation instructions.
The systems that does not have any SNAP cartridges installed
(the SNAP 10 g, 25 g, 50 g, 100 g and 340 g will be installed)