Evaluation of a Novel Low-Volume 96-well SPE Format for Forensic and Clinical Toxicology Prior to UHPLC-MS/MS Analysis

Miniaturisation within various fields of analytical chemistry is not a new phenomenon. Early phase small animal drug trials have largely been the driver due to limited sample sizes available. However, this trend is gaining popularity in forensic/clinical toxicology with respect to alleviating patient discomfort, particularly in paediatrics. Increased LC-MS/MS sensitivity has reignited this focus area. This poster will evaluate a novel low-volume 96-well solid phase extraction (SPE) format and potential application to forensic and clinical toxicology. ASMS, 2020.