Documents | Sample Preparation Method for Determination of Mycophenolic Acid in Plasma Using ISOLUTE® SLE+

Sample Preparation Method for Determination of Mycophenolic Acid in Plasma Using ISOLUTE® SLE+

In this application note, ISOLUTE® SLE+ was used as a sample pretreatment column for mycophenolic acid determination in plasma using supported liquid extraction (SLE). UV based methods are commonly used to measure mycophenolic acid. In this application note, we have developed a method that can be used for both UV measurement and LC/ MS/MS measurement. LC/MS/MS assays are highly selective and less susceptible to the effects of other drugs used in combination during treatment.

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Biotage is the Global Go-To Separations Company, supporting customers from drug discovery and development through to diagnostics and analytical testing with intelligent and sustainable workflow solutions. Our expertise and top-tier separation solutions play a key role in streamlining our customers’ workflows and improving their outcomes. Headquartered in Sweden, Biotage operates globally with 700 employees, serving over 80 countries. Our company is listed on NASDAQ Stockholm (BIOT).

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Sample Preparation Method for Determination of Mycophenolic Acid in Plasma Using ISOLUTE® SLE+