Part No: AN757Issued year: 2012File size: 1.61mbFile type: pdf
Vitamin D deficiency can result in a variety of health issues such as osteoporosis, liver and kidney problems, it is often associated with increased risk of cancers and multiple sclerosis. From this standpoint vitamin D monitoring is on the rise and of significant clinical relevance. This method describes the use of ISOLUTE SLE+ plates for the efficient and simple extraction of the vitamin D metabolites 25-OH vitamin D2 and 25-OH vitamin D3. Incorporated into the procedure is an integral protein binding disruption step which maximizes analyte recovery and eliminates the need for any offline protein disruption. This method has been internally validated using DEQAS approved serum samples and deuterated internal standards the results obtained are better than that required for criteria for acceptable performance for
DEQAS approval. All recoveries were consistently greater than 90% with all RSDs < 10% at LOQs of 1-3.75 ng/mL.
Vitamin, Vitamin D, VitaminD, D, Clinical, SLE+, SLE, ISOLUTE, Metabolites, Supported Liquid Extraction, 25 Hydroxy Vitamin D,
Part No: AN706Issued year: 2011File size: 0.1mbFile type: pdf
The following methods have been developed for the selective extraction of beta-agonists from biological matrices. Methods have been developed for both biological tissues (e.g. bovine muscle) and fluids (e.g. urine). The methods are highly reproducible and offer β-agonist recoveries in the range of 35-90%.
MIP, Molecularly Imprinted Polymers, BIOTAGE, AFFINILUTE, SupelMIP,
Part No: Issued year: 2013File size: 0.52mbFile type: pdf
Developed in collaboration with the OC Crime Lab, this poster describes the extraction of 25 benzodiazepines and sedatives from various matrices using ISOLUTE SLE+ Supported Liquid Extraction columns. This poster was presented at SOFT 2013.
Part No: P225Issued year: 2020File size: 0.34mbFile type: pdf
New, novel benzodiazepines have become some of the most abused unique psychoactive substances seen today. In the United States, these compounds are not approved for prescription use. Therefore, the demand for testing of these drugs has rapidly increased, both in the United States and worldwide. Urine and whole blood are common matrices of choice for forensic laboratories as they can be easy to collect, and they provide relevant information regarding recent or active use of illicit materials.
Part No: Issued year: 2010File size: 1.23mbFile type: pdf
User report: Initiator. Prof. Nakamura at the Gakushuin University has described the Initiator as an essential tool for his group’s cutting-edge research. We asked Prof. Nakamura for his views on the latest trends in the fields of organic synthesis and drug discovery.
Part No: P049Issued year: 2012File size: 0.27mbFile type: pdf
This poster outlines a new method for the extraction of a mixture of peptides from plasma using resin based SPE. Initial method optimization was performed using EVOLUTE ABN before comparison to the streamlined approach without plate conditioning and equilibration using EVOLUTE EXPRESS ABN. Presented at EBF 2012.
EBF, EBF 2012, Peptide, ABN, SPE, Polymer, Polymeric,