Part No: AN095-HORIssued year: 2014File size: 2.85mbFile type: pdf
The global demand for fish as a natural source of fresh animal protein, essential fats, minerals, and vitamins continues to rise with the human population. It is estimated that natural fish resources will not be sustainable, creating the need to increase the available supply of fish through aquaculture.
Part No: AN106-HORIssued year: 2016File size: 1.4mbFile type: pdf
Worldwide, there is great concern for the presence of semi-volatile organic compounds in surface water, groundwater, and drinking water, such as Aldrin, extremely toxic to fish and a persistent organic pollutant. China has increased concern about drinking water as sources of surface and groundwater have become polluted with microbiological, metal and organic contamination
Part No: AN063Issued year: 2012File size: 0.48mbFile type: pdf
Pyrazines are a class of organic molecules often used to provide flavor to foods. They are typically synthesized but some are found in fruits and vegetables, e.g. grapes, bell peppers, peas, asparagus, beetroot, tobacco, and roasted foods. Pyrazine’s heterocyclic chemistry can yield some challenges to their purification due to the various separation kinetics between the compound and silica. Biotage SNAP Ultra.
Part No: AN123-HOR.V.1Issued year: 2017File size: 2.46mbFile type: pdf
The US EPA monitors a variety of chemicals in water that may cause harm to humans or wildlife in order to minimize exposure. Method 625 was developed by the Office of Science and Technology in the Clean Water program to monitor a large suite of semivolatile chemicals in wastewater for compliance with the National Pollution Discharge Elimination System (NPDES). NPDES is a system of permitting that regulates the characteristics of water that is released into a waterway, defined by industrial category. The permitting levels are set depending on the waterway’s use.
Part No: P160Issued year: 2017File size: 0.24mbFile type: pdf
Although capable of very high resolution, RP-HPLC is often limited by low column loading capacity, therefore demanding a significant time investment for peptide purification. As an alternative strategy, reversed-phase flash chromatography can also be used to purify synthetic peptides. The larger particle size used in flash column chromatography enables much larger loading capacity, thereby significantly reducing the time required for peptide purification.
Part No: PPS375.v1Issued year: 2015File size: 0.3mbFile type: pdf
User report: Flash instruments. Chugai Pharmaceutical uses Biotage flash chromatography products for drug discovery research. When deciding to convert from manual open-column procedures to automated systems, they chose successive generations of Biotage products, ranging from the Flash+® packed column to the Biotage® Horizon, SP1, Isolera™ Spektra, and Isolera™ Dalton automated flash chromatography systems.
Part No: PPS569Issued year: 2019File size: 0.94mbFile type: pdf
I met with Professor Sabra Botch-Jones in the Boston University Medical campus to talk about her career in forensic chemistry. During this interview, I learnt more about forensics than I’ve ever learned watching NCIS, and gained an insight into her fascinating career.
Part No: AN041Issued year: 2001File size: 0.16mbFile type: pdf
Normal-phase flash purification is commonly used by organic chemists in pharmaceutical drug discovery and
process development labs. However, for many synthesized products (e.g. peptides, nucleotides and basic
drug candidates) purification on standard flash silica is not an option due to irreversible adsorption, chemical
interaction and/or solubility issues. Reversed-phase flash purification is an excellent solution for these applications. Yet, this technique has been used sparingly because of perceived lower loading capacity, higher
operating pressures and a scarcity of publications addressing reversed-phase flash chromatography.
Part No: AN942Issued year: 2020File size: 1.63mbFile type: pdf
The purpose of this application note is to optimize the solution for the removal and testing of total n-hexane extractable material (HEM) using solid phase extraction in combination with the Biotage® Horizon 5000 automated extraction system.
Part No: AN082-HORIssued year: 2012File size: 0.85mbFile type: pdf
The focus of this Application Note is to illustrate some of the advances which have been made when performing EPA method 525.2 when using Solid Phase Extraction (SPE). It will make use of the Biotage(r) Horizon SmartPrep Automated Cartridge Extraction system set up to run in Bottle Rinse Mode with 6 mL SPE cartridges.
Part No: AN084-HORIssued year: 2012File size: 1mbFile type: pdf
Within EPA Method 549.2, the suggested rate to load a sample onto a solid phase cartridge is given as 3 to 6 mL/min.
This Application Note outlines the process used to extract diquat and paraquat from water samples using a faster loading rate than given by the EPA in method 549.2
Part No: TN128Issued year: 2006File size: 0.09mbFile type: pdf
This technical note describes the use of derivatization techniques to separate aliphatic
secondary amines from aliphatic tertiary amines in a mixture using the strong cation
exchange sorbent, ISOLUTE® SCX-2.
Part No: AN062-HORIssued year: 2011File size: 0.82mbFile type: pdf
Oftentimes, aqueous samples collected contain varying amounts of suspended solids or sediment strictly due to either the source of the water being sampled or improper sampling techniques. In any circumstance, samples with high amounts of particulates or sediment have proven challenging to extract using EPA Method 3535 Solid Phase Extraction (SPE).
Part No: PPS385Issued year: 2015File size: 4.87mbFile type: pdf
Our carefully selected portfolio of industrial scale products have a proven track record of successful applications and use in scale-up projects. We can support the discovery, development and manufacturing of customer pharmaceutical and biotechnology products, from pre-clinical, phase I, II and III to small scale commercial operations.