
Isolera™ Prime » Isolera™ Spektra Systems with ACI™ and Assist »
The UV absorption spectrum of some solvents
overlaps with the product they dissolve, meaning
that fraction collection processes cannot distinguish
between solvent and product. Luckily, there is
technology that solves this problem.
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Application Notes
This application note outlines how to use the Isolera system to perform a size-exclusion separation as part of a sample clean up method defined by the EPA, a key sample preparation step in environmental laboratories.
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Application Notes
Biotage has developed a range
of tools to improve the peptide synthesis workflow,
from synthesis of crude peptides through to the final
purified product. These solutions make your workflow
more efficient and improve the quality of peptides
you synthesize. Our workflow solutions are used in
pharma, biotech, CRO and academic laboratories
throughout the world.
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Brochures
Biotage has developed tools for every
step of the organic process, with the entire workflow in mind.
This dedicated suite of products vastly expands the
range of options in order to truly accelerate discoveries
of new molecules for future innovations.
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Brochures
This brochure presents the extensive range of instrumentation for flash purification from Biotage. To complement these products Biotage also offers a complete range of flash consumables, including columns in a variety of sizes packed with irregular and spherical silica, making Biotage your one-stop partner for your flash purification needs.
Keywords: Isolera™ Dalton, Isolera™ Spektra, 10 Isolera™ Spektra One and Four, Isolera™ Spektra LS (Large Scale), Isolera™ Prime, Isolera™ ELSD-1080, Biotage® Flash 75/150, Biotage® Flash 400
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Brochures
Ease of use is what stands out as the top feature of Isolera™ flash chromatography
system for Professor Anna Bernardi, head of the synthetic organic chemistry
research group at the University of Milan. Her current research goal: developing
sugar-like molecules, called glycomimetics, for healthier life.
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Customer Cases
To add Biotage® Sfär columns to an Isolera, you must choose
Data Administration from the Main Menu.
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Manuals & User Guides
How to Install Isolera SW 2.3
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Manuals & User Guides
Flash purification involves a simple liquid chromatography technique
» Method development uses TLC as a way of deciding the parameters for the
separation
» Isocratic separations are easiest to develop, but gradient separations are
more powerful
» Software in the Isolera helps with conversion of an isocratic separation to
a gradient
» It is possible with the Spektra software to run step gradients
» Loading options are dependent on the column type
» SNAP offers the most flexibility
» Care must be taken to choose the best loading option to get good
purifications
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Manuals & User Guides
Preparation, How Much are You Purifying?
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Manuals & User Guides
The Isolera leak detection system is designed with safety in
mind. Unlike vapor sensing devices with unreliable solvent
vapor sensitivity, the Isolera leak detector’s sensitive,
solvent-resistant refractive index (RI) monitor rapidly
signals the Isolera flash system to stop pumping if any
liquid, volatile or non-volatile, is detected thus protecting
the chemist, system, and lab from potential hazards.
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Manuals & User Guides,
Product Notes
New, higher default flow rates enabled by Isolera ACI systems decreases purification times compared to other systems’ and cartridges’ default flow rate settings without sacrificing separation efficiency. Incorporation of gradient optimization by converting a linear gradient to a step gradient further reduces purification time and solvent use while maintaining separation integrity for a target molecule.
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Posters
In order to obtain a fast synthesis of an N-unprotected tripeptide, microwave (mw) assisted deprotection, coupling and partial deprotection were applied starting with a purified protected dipeptide [Fig. 1]. The three consecutive mw assisted steps were performed without any intermediate purifications and were accomplished within some 30 minutes. The resulting crude mixture containing the Boc deprotected tripeptide ester was shown to be quite complex [Fig. 2]. The crude product was subjected to automated reversed phase flash chromatography, followed by automated fraction pooling and “thin film evaporation”. The total time for the entire procedure was 1 h 20 min. The purity of the product was > 99%.
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Posters
Bei herkömmlichen Aufreinigungsverfahren mittels Chromatographie kommen große Mengen verhältnismäßig giftiger und teurer Lösungsmittel zum Einsatz, die sich negativ auf den ökologischen Fußabdruck von Unternehmen in der Molekularforschung auswirken. Neue Richtlinien für einen verantwortungsvolleren Umgang mit Chemikalien zwingen Unternehmen, die Umweltauswirkungen ihrer Arbeit zu reduzieren. Durch Einblicke in die Arbeitsabläufe dieser Unternehmen und neue Entwicklungen im Bereich Flash-Chromatographiesysteme und -säulen lassen sich Verbrauch und Toxizität der für die Aufreinigung eingesetzten Lösungsmittel und somit auch die Umweltbelastungen dieser Verfahren reduzieren.
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Environmental,
German,
Product Notes,
White Papers
Modelle haben gezeigt, dass sich die zur Herstellung
eines Zielmoleküls benötigte Zeit mit dem automatisierten
Workflow von Biotage um bis zu achtzig
Prozent verkürzen lässt, sodass auch die Projektlaufzeiten
entsprechend verkürzt werden können.
Tags:
German,
Product Notes,
White Papers
Using the Biotage automated workflow, models have shown that the time taken to produce a target molecule can be reduced by up to eighty percent, allowing project delivery timescales to be reduced
accordingly.
Tags:
Product Notes,
White Papers
Traditional approaches to compound purification involving chromatography utilize large volumes of relatively toxic and expensive solvents, and significantly contribute to the environmental footprint of organizations involved in molecular research. Current directives for greener chemistry have put pressure on organizations to reduce the
environmental impact of their work.
Tags:
Environmental,
Product Notes,
White Papers
With running costs and time a concern in most labs, ACI™ now promises to take users to the end point even faster and even more efficiently.
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Product Notes
Biotage ZIP flash chromatography cartridges are engineered to meet the needs of chemists requiring high performance and consistency from a purification cartridge at a value price to reduce purification costs.
Isolera Prime flash purification system.
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Product Notes
Isolera™ is a new, more compact, flash purification system
with intelligent features that enable chemists to easily
achieve better separations.
Tags:
Product Notes
The Isolera leak detection system is designed with safety in
mind. Unlike vapor sensing devices with unreliable solvent
vapor sensitivity, the Isolera leak detector’s sensitive,
solvent-resistant refractive index (RI) monitor rapidly
signals the Isolera flash system to stop pumping if any
liquid, volatile or non-volatile, is detected thus protecting
the chemist, system, and lab from potential hazards.
Tags:
Manuals & User Guides,
Product Notes
Die Flash-Chromatographie ist die bevorzugte
Reinigungsmethode für organische Stoffe, Arzneimittel und
Naturstoffe. In jüngster Zeit hat sie auch die Peptidchemie
erobert, verfügt sie doch über die Fähigkeit, eine Vielzahl
unterschiedlicher Verbindungen effizienter zu trennen, als dies
mit anderen Vorreinigungsverfahren wie z. B. dem Ausfällen
(Protein-Crash) oder der Flüssig-Flüssig-Extraktion möglich ist.
Zur Herstellung reiner Verbindungen können Chemiker je nach
dem gewünschten Reinheitsgrad auf eine Vielzahl unterschiedlicher
Variablen zurückgreifen. In diesem Whitepaper möchten
wir die Faktoren erläutern, die für eine erfolgreiche Aufreinigung
mithilfe der Flash-Chromatographie kontrolliert werden müssen.
Tags:
White Papers
Bei herkömmlichen Aufreinigungsverfahren mittels Chromatographie kommen große Mengen verhältnismäßig giftiger und teurer Lösungsmittel zum Einsatz, die sich negativ auf den ökologischen Fußabdruck von Unternehmen in der Molekularforschung auswirken. Neue Richtlinien für einen verantwortungsvolleren Umgang mit Chemikalien zwingen Unternehmen, die Umweltauswirkungen ihrer Arbeit zu reduzieren. Durch Einblicke in die Arbeitsabläufe dieser Unternehmen und neue Entwicklungen im Bereich Flash-Chromatographiesysteme und -säulen lassen sich Verbrauch und Toxizität der für die Aufreinigung eingesetzten Lösungsmittel und somit auch die Umweltbelastungen dieser Verfahren reduzieren.
Tags:
Environmental,
German,
Product Notes,
White Papers
Modelle haben gezeigt, dass sich die zur Herstellung
eines Zielmoleküls benötigte Zeit mit dem automatisierten
Workflow von Biotage um bis zu achtzig
Prozent verkürzen lässt, sodass auch die Projektlaufzeiten
entsprechend verkürzt werden können.
Tags:
German,
Product Notes,
White Papers
Using the Biotage automated workflow, models have shown that the time taken to produce a target molecule can be reduced by up to eighty percent, allowing project delivery timescales to be reduced
accordingly.
Tags:
Product Notes,
White Papers
Traditional approaches to compound purification involving chromatography utilize large volumes of relatively toxic and expensive solvents, and significantly contribute to the environmental footprint of organizations involved in molecular research. Current directives for greener chemistry have put pressure on organizations to reduce the
environmental impact of their work.
Tags:
Environmental,
Product Notes,
White Papers
Our Deuterium Lamps... Detect compounds with UV light. Detect compounds with UV light. Ensure peak Isolera™ system performance Undergo extensive pre-delivery quality checks Guarantee 1...
12 December 2018You can make the new Biotage® Sfär flash columns appear in the cartridge list on Isolera™ systems, following this step-by-step guide. Download it below and purify away. The gu...
09 August 2018Want to improve your flash chromatography skills? Learn all the tricks of the trade in this one-hour webinar with flash guru Bob Bickler. For a dedicated synthetic chemist, the goal ...
13 July 2017Biotage is pleased to announce the release of the new Peptide Synthesis Workflow – Synthesis, Purification, and Evaporation Solutions Brochure The typical peptide synthesis workflow broadly ...
05 April 2017Ease of use is what stands out as the top feature of Isolera™ flash chromatography system for Professor Anna Bernardi, head of the synthetic organic chemistry research group at the University...
12 April 2016The industry standard platform for flash purification, Isolera™, is given a basic presentation by our Italian account manager in this short video. Isolera è una gamma di...
18 March 2016The industry standard platform for flash purification, Isolera™, is given a basic presentation by our German account manager in this short video. Isolera™ ist ein Flash C...
11 December 2014The UV absorption spectrum of some solvents overlaps with the product they dissolve, meaning that fraction collection processes cannot distinguish between solvent and product. The phenomenon, ...
12 September 2014The capabilities of Biotage flash chromatography systems for providing pure compounds from natural products is confirmed in an extensive Korean study of active compounds in the medicinal herb&...
09 September 2014ACI™ - Accelerated Chromatographic Isolation radically improves the efficiency of the laboratory, embracing the latest developments in purification technology to guide chemists towards improv...
07 August 2014Flash Purification Has Come of Age Flash purification is a chromatographic technique developed with one goal in mind – to deliver the maximum amount of purified product in the minimum ...
27 June 2014Uppsala, Sweden, 27th June, 2014 – Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, announces the launch of ACI&trad...
14 May 2014This study shows how the flash chromatography system Isolera™ can perform a size-exclusion separation according to an EPA sample clean up method - a key step in environmental laboratories. I...
14 March 2014By Dr. Greg Saunders, EU Marketing Manager for Organic and Peptide Chemistry at Biotage Liquid chromatography (LC) is used for two different purposes – analytical work and purification &ndas...
11 February 2013Uppsala, Sweden, 1st February, 2013 Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, has announced the launch of an updat...
04 September 2012Uppsala, Sweden, 4th September, 2012 Biotage (STO: BIOT), a leading global supplier of solutions and technology for analytical, medicinal and peptide chemistry, announces that Biotage is in late s...
15 June 2012Dr. Sunil Rana, product manager at Biotage, explains the advanced features for flash chromatography in the new Isolera™ Spektra release. Watch the free webinar recording here >
26 April 201223 April 2012 Product manager Bob Bickler introduces the new time-saving Isolera™ Spektra features for Isolera One, Four and LS Flash chromatography instruments.
02 November 2011November 1, 2011 Uppsala, Sweden – Biotage® (STO: BIOT), a leading manufacturer of tools and technology for medicinal, organic, and analytical chemistry, introduced the new Isolera PrimeT...
18 October 2011Preparative FLASH chromatography expedites the production of clinical trial compounds. Tobi Williams is an application chemist specializing in pilot and production purification at Biotag...
16 August 2010Charlotte, North Carolina, USA, August 16, 2010 – Biotage (STO: BIOT), a leading developer of tools and technology for medicinal and analytical chemistry, announces the introduction of the Is...
21 April 2010Uppsala, Sweden, April 20, 2010 – Biotage (STO: BIOT), a global leader in automated flash purification, tools and technology for medicinal and analytical chemistry, announced it has recently ...
23 February 2010Uppsala, Sweden, February 23, 2010 – Biotage, a leading supplier of tools and technology for medicinal and analytical chemistry, announced the launch of enhanced gradient optimization (GO) te...
27 October 2008October 28, 2008 Biotage, a leading supplier of tools and technology for medicinal and analytical chemistry, announces the release of its new 2008–09 Synthesis and Purification Catalog. The ...
29 May 2008News release Contact: Jennifer Whedbee, Director Marketing Communications Tel: +1 434 220 2652, jwhedbee@biotage.com Biotage Introduces New Isolera™ FLASH Purification System for Faster Sepa...
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ISO-PSF | Isolera Prime, One Channel, Single Collection Bed, Fixed Detector | Instruments | 1 | Log in for price | |
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ISO-PSV | Isolera Prime, One Channel, Single Collection Bed, 200-400 nm Detector | Instruments | 1 | Log in for price |
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413013 | Isolera, FC tubing kit (Includes two different tubes) | Spare parts | 1 | Log in for price |