Performance Comparison - Biotage® Sfär Silica HC Duo vs. Biotage® SNAP Ultra on Isolera™

For flash purification, Biotage®  Sfär Silica High Capacity Duo replaces the older Biotage®  SNAP Ultra product line. The Sfär columns offer significant advantages over the SNAP Ultra range:
» New 5 g and 200 g columns
» All spherical 20 µm media
» Increased pressure rating
» CE marked
» Fast pressure-driven equilibration when used with the Biotage® Selekt system, giving huge solvent savings
» New improved packaging
» Clearer labels and QR code when used with the Selekt system

The majority of these advantages are new features that can be of benefit regardless of which flash purification instrument is used to run the column. However, the main performance advantage of increased pressure capability (and associated higher flow equilibration) requires the use of the Biotage®  Selekt flash purification system. So are there any performance advantages of the new columns that are of benefit to Isolera users? To investigate this, the separation of three phthalates was investigated on the Sfär Silica High Capacity Duo 25 g and equivalent SNAP Ultra columns on the Isolera system.