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How to Purify Organic Amines

04 June 2015

If you are making amine functionalized organic molecules, and you find it challenging to purify them with normal-phase silica, you are not alone. 

 

If you synthesize organic amine compounds, especially heterocyclic, secondary, or tertiary amines, you likely have encountered problems with their chromatography using silica columns. With the amine groups being basic and silica being acidic, there is a natural attraction between the two. This sometimes strong attraction often requires the use of a competing amine in the solvent system. 

This post on the Flash Purification Blog discusses how amine-functionalized silica can simplify organic amine purification. 

Read More

Is there an easy way to purify organic amines?

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